Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21044

Enrollment

Registered

2011-03-29

Start date

2011-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

TEA-RV function- ventricular pulmonary coupling

Interventions

Right ventricular function will be assessed by invasive pressure-volume loop analysis using combined pressure-conductance catheters. The response of right ventricular function to increased afterload,

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing lungresection.

Exclusion criteria

Exclusion criteria: Contra indication epidural anesthesia.

Design outcomes

Primary

Measure	Time frame
Pressure–volume signals acquired during steady state yield end-diastolic and end-systolic volume (EDV, ESV), ejection fraction (EF), end-diastolic and end-systolic pressure (EDP, ESP), stroke work (SW), dP/dtMAX and dP/dtMIN, and isovolumic relaxation time constant Tau. The end-systolic pressure–volume relation (ESPVR: ESP vs. ESV) and the preload recruitable stroke work relation (PRSWR: SW vs. EDV) quantify systolic ventricular function. The slope of the ESPVR determines end-systolic elastance Ees. The end-diastolic pressure-volume relation (EDPVR: EDP vs. EDV) is used to determine diastolic function, quantified by diastolic chamber stiffness and the stiffness constant. Right ventricular afterload is determined by effective arterial elastance Ea, calculated as ESP/SV. Ventricular-arterial coupling is quantified as Ees/Ea.	—

Measure

Time frame

Pressure–volume signals acquired during steady state yield end-diastolic and end-systolic volume (EDV, ESV), ejection fraction (EF), end-diastolic and end-systolic pressure (EDP, ESP), stroke work (SW), dP/dtMAX and dP/dtMIN, and isovolumic relaxation time constant Tau. The end-systolic pressure–volume relation (ESPVR: ESP vs. ESV) and the preload recruitable stroke work relation (PRSWR: SW vs. EDV) quantify systolic ventricular function. The slope of the ESPVR determines end-systolic elastance Ees. The end-diastolic pressure-volume relation (EDPVR: EDP vs. EDV) is used to determine diastolic function, quantified by diastolic chamber stiffness and the stiffness constant. Right ventricular afterload is determined by effective arterial elastance Ea, calculated as ESP/SV. Ventricular-arterial coupling is quantified as Ees/Ea.

—

Secondary

Measure	Time frame
ECG, Heart rate (beats/min), NIBP (mmHg), SpO2 (%), Systolic Blood Pressure (mmHg), Diastolic Blood Pressure (mmHg), Mean Arterial Pressure (mmHg), Cardiac Output (l/min).	—

Contacts

Public ContactJ. Wink

Consultant (cardiothoracic) anaesthesiology Department of Anaesthesiology LUMC, P5Q-32 2300 RC

j.wink@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)