diabetes type 2 suikerziekte ouderdomssuikerziekte diabetes
Conditions
Interventions
High caloric diet during 6 days.
Sponsors
Prof. dr. H. Pijl, internist-endocrinoloog
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy males; 2. Healthy diet; 3. Age 19-29; 4. BMI 19-25 kg/m2; 5. Stable weight for the last 2 years; 6. Caucasian; 7. FPG 7.5 mmol/l; 9. No family history of DM2.
Exclusion criteria
Exclusion criteria: 1. Use of medication known to affect glucose metabolism (for example prednisone) or lipid metabolism; 2. History of genetic or psychiatric disease (e.g. fragile X syndrome, major depression) that affects the brain; 3. Significant chronic disease; 4. Renal or hepatic disease; 5. Recent weight changes or attempts to loose or gain weight (> 3 kg weight gain or loss, within the last 3 months); 6. Smoking (current); 7. Alcohol consumption of more than 28 units per week at present or in the past; 8. Recent blood donation (within the last 3 months); 9. Recent participation in other research projects (within the last 3 months); 10. Participation in 2 or more projects in one year; 11. Sleep disorders; 12. Contra-indication to MRI scanning: A. Claustrophobia; B. Pacemakers and defibrillators; C. Nerve stimulators; D. Intracranial clips; E. Intraorbital or intraocular metallic fragments; F. Cochlear implants; E. Ferromagnetic implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. FMRI scans of hypothalamus; 2. Polysomnography/MSLT. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Metabolomics; 2. Inflammatory markers; 3. Oral glucose tolerance test; 4. Gut hormones. | — |
Contacts
Public ContactM.A. Wijngaarden
Outcome results
None listed