Breast cancer, cognitive problems, borstkanker, cognitieve problemen
Conditions
Interventions
A 6-month exercise program consisting of aerobic and strength exercise supervised by a physiotherapist (2 hrs/w) and Nordic or Power Walking (2 hrs/w). Controls will be asked to retain their usual phy
Sponsors
University Medical Center Utrecht (UMCU)
Eligibility
Inclusion criteria
Inclusion criteria: cancer patients adjuvantly treated with chemotherapy with or without endocrine therapy, 2-4 years after cancer diagnosis, 30-75 years of age, no indication of relapse or metastases, exercise ¡Ü 150 min/week, self-reported cognitive problems, lower than expected performance on neuropsychological testing, mastering the Dutch language and willing to be randomly assigned to one of the two study arms.
Exclusion criteria
Exclusion criteria: We will exclude patients with known neurological conditions and/or diseases that affect cognition (e.g. dementia, MS, TBI), disorders that might impede exercise participation, contra indications for MR imaging, treated for breast cancer in both breasts; and patients switching from Tamoxifen to aromatase inhibitors during the study period or four months before
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome parameters are: cognitive functioning (the total recall score of the HVLT-R as our primary outcome measure) and self-reported cognitive complaints (MDASI-MM module, 2 symptom severity questions on memory and attention and 6 symptom interference items). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include overall cognitive functioning measured by standard neuropsychological tests, brain structure and function (3 Tesla brain MRI), anthropometrics, physical fitness, QOL, fatigue, anxiety and depressive symptoms, and work performance. | — |
Contacts
Public ContactEvelyn Monninkhof
University Medical Center Utrecht (UMCU), Julius Center for Health Sciences and Primary Care, Stratenum 6.131, P.O. Box 85500
Outcome results
None listed