Breast Cancer
Conditions
Interventions
Patients will undergo standard diagnostics and work-up according to the Dutch National Guidelines, including the marker placement procedure. During the marker placement procedure an accessory tumor ti
Sponsors
Maastricht University Medical Center +
Eligibility
Inclusion criteria
Inclusion criteria: - Female, - >18 years, - Breast cancer (proven by histopathology), - Undergoing the marker placement procedure.
Exclusion criteria
Exclusion criteria: - Physically or mentally incapable or incompetent to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To develop a patient derived clinical model of breast (cancer) organoids using tissue biopsies. | — |
Secondary
| Measure | Time frame |
|---|---|
| Histological, genomic, and proteomic analysis will be conducted to provide insight in whether these organoids are patient representative and could result in patient tailored treatment. Furthermore, existing and newly developed therapies will be tested on this model - with the ultimate goal, to predict therapy response and/or resistance. Therapy efficacy will be assessed using viability assays, and genomic- and proteomic analysis. | — |
Contacts
Public ContactM.L. Smidt
P.O. box 5800
Outcome results
None listed