Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder.

Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder and treatment effects of cognitive behavioral therapy.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20975

Enrollment

Registered

2006-06-27

Start date

2006-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

1. 16 weekly sessions Cognitive Behavioral Therapy (CBT)

2. Waitlist (8 weeks) followed by 16 weekly sessions CBT.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Children and adolescents 8 - 18 years; 2. Primary diagnosis: Obsessive Compulsive Disorder (OCD); 3. OCD symptoms for more than 6 months; 4. CY-BOCS total score > 16; 5. IQ > 80; 6. Informed consent of parents and child.

Exclusion criteria

Exclusion criteria: Use of the following medication: 1. SSRI; 2. TCA; 3. Anti-psychotic medication. For neurobiological measures (fMRI): 1. Claustrophobia; 2. Metal on body.

Design outcomes

Primary

Measure	Time frame
1. Severity of OCD (CY-BOCS; measured at the start of the waitlist condition, directly before start of the CBT, session 4, 8, 12 and 16 and follow up after 16 weeks); 2. Anxiety / Depression (RCADS) measured at the start of the waitlist, directly before start of the CBT, at the end of the therapy (session 16) and follow up after 16 weeks).	—

Secondary

Measure	Time frame
1. Information-processing (explicit: OBQ-44 R, MCQ-A; Implicit: EAST) (measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks); 2. Inhibition / selective attention (Dot Probe; measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks); 3. Neuroimaging data: volumes grey and white matter, activity on planning (tower of London), selective attention (Flanker) and inhibition (DOT-probe)task in fMRI.	—

Measure

Time frame

1. Information-processing (explicit: OBQ-44 R, MCQ-A; Implicit: EAST) (measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks); 2. Inhibition / selective attention (Dot Probe; measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks); 3. Neuroimaging data: volumes grey and white matter, activity on planning (tower of London), selective attention (Flanker) and inhibition (DOT-probe)task in fMRI.

—

Contacts

Public ContactL.H. Wolters

Academic Medical Center (AMC), Department of Child and Adolescent Psychiatry, Meibergdreef 9

L.h.wolters@amc.uva.nl+31 (0)20 5662242

Outcome results