Effect of early mobilisation combined with additional protein on muscle mass in critically ill patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20948

Enrollment

Registered

2018-02-02

Start date

2018-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decline in muscle mass during ICU admission.

Interventions

Intervention group: Optimal feeding (proteins 1.5 g/kg), early mobilization (3 times a day), directly after mobilization additional 15 grams of proteins. Control group: Optimal feeding (proteins 1.5 g

Eligibility

Inclusion criteria

Inclusion criteria: - Included and randomized in the study within 48 hours after ICU admission. - Expected to stay on the ICU for at least 72 hours. - Complete enteral nutrition. Or enteral nutrition in combination with parenteral or oral nutrition.

Exclusion criteria

Exclusion criteria: -Complete parenteral feeding -> administration of ProSource not possible -Chronic renal failure or hepatic encephalopathy -> absolute contraindications of supplemental protein -Acute kidney injury without CVVH or IHD -> relative contra-indication.22 -Poor prognosis (Anticipated mortality within 72 hours) -Progressive neuro-muscular disease or neurotrauma

Design outcomes

Primary

Measure	Time frame
Muscle thickness of the mid-upper arm, forearm and thigh measured by ultrasonography	—

Secondary

Measure	Time frame
• muscle quality (echogenicity determined with ultrasonography); • nutritional state and hydration status (Biva measurement); • muscle force (MRC-sum and handgrip force); • functional status (DEMMI); • quality of life (EQ-5D);	—

Contacts

Public ContactMarieke Kloosterman

Postbus 310

m.kloosterman@rrd.nl+31 (0)53 4875777

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)