Postpoliomyelitis Syndrome, Neuromuscular diseases, Fatigue, Skeletal muscle, Aerobic capacity Postpoliomyelitis Syndroom, Neuromusculaire aandoeningen, Vermoeidheid, (Skelet)spieren, Aerobe inspanning
Conditions
Interventions
None listed
Sponsors
Academic Medical Center (AMC), Department of Rehabiliation
Eligibility
Inclusion criteria
Inclusion criteria: Patients: Diagnosis of PPS according to the criteria of March of Dimes (2000)*: 1. A confirmed history of paralytic poliomyelitis characterized by an acute illness with fever and a usually asymmetrically distributed, flaccid paresis of a varying number of muscle groups. Evidence of motor neuron loss on neurological examination with signs of residual weakness, atrophy, loss of tendon reflexes and intact sensation; 2. A period of partial or complete functional recovery after acute paralytic poliomyelitis, followed by an interval (usually 15 years or more) of stable neurologic function; 3. Gradual or sudden onset of progressive and persistent new muscle weakness or abnormal muscle fatigability (decreased endurance), with or without generalized fatigue, muscle atrophy, or muscle and joint pain. Symptoms persist for at least a year; 4. No other medical diagnosis to explain the symptoms. Control subjects: Healthy volunteers, matched for age, physical activity level, gender, body weigth and height. *March of Dimes Birth Defects Foundation. Identifying Best Practices in Diagnosis & Care Warm Springs, GA: March of Dimes International Conference on Post-Polio Syndrome. 2000.
Exclusion criteria
Exclusion criteria: Patients and control subjects: 1. Disabling co-morbidity influencing the outcome parameters (including cardiopulmonary disease like chest pain, arrhythmia, pacemaker, cardiac surgery, severe dyspnoea d’effort or emphysema, epileptic seizures, poorly regulated diabetes mellitus); 2. Inability to cycle on a bicycle ergometer; 3. Inability to activate the knee extensor muscles.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variables for peripheral muscle properties include: 1. Critical torque (Nm); 2. Fatigue index (%); 3. Rate of torque development/decline (%)These will be determined with maximal voluntary contractions and (submaximal) electrically evoked contractions of the knee extensor muscles. Variables for aerobic exercise capacity include: 1. VO2peak (ml/min/kg); 2. VO2 at anaerobic threshold (ml/min/kg); 3. Power output at anaerobic threshold (W); 4. Heart rate at anaerobic threshold (bpm). These will be determined during graded exercise testing on a cycle ergometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple measures of muscle strength and muscle activation will be determined: 1. Maximal Voluntary Contraction (MVC) (Nm); 2. Voluntary Activation (%); 3. Peripheral fatigue and Central fatigue (%). | — |
Contacts
Public ContactE.L. Voorn
PO Box 22660
Outcome results
None listed