Onthullen van moleculaire en cellulaire mechanismen die verband houden met veroudering van de schouderspieren en het optreden van een rotator cuff scheur.

Unraveling the molecular and Cellular muscular mechanisms associated with Aging in rotator cuff Tears of the Shoulder

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20921

Enrollment

Registered

2014-08-07

Start date

2014-06-19

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rotator cuff degeneration rotator cuff tears

Interventions

biopsies of subscapular muscle and deltoid muscle

Eligibility

Inclusion criteria

Inclusion criteria: MRI proven shoulder pathology for which shoulder surgery is needed.

Exclusion criteria

Exclusion criteria: - Age 80 years - No informed consent - Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), rheumatoid arthritis, polymyalgia rheumatic, heart failure, COPD (Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc) - Metabolic diseases (e.g. insuline dependent DM) - Cancer

Design outcomes

Primary

Measure	Time frame
RNA profiling difference between subscapular and deltoid muscles and its correlation to magnetic resoncace imaging	—

Secondary

Measure	Time frame
cell proliferation cell apoptosis mitochondrial activity cell fusion cell senescence Constant score Range of motion Muscle Strength DASH WORC MR features including: - fatty infiltration - cross sectional surface area	—

Contacts

Public ContactR.G.H.H. Nelissen

Leiden University Medical Center (LUMC), Postbus 9600

R.G.H.H.Nelissen@lumc.nl+31 (0)71 5269111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)