Does hypothyroidism induced by thyroid hormone withdrawal lead to permanent modifications of the DNA?

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20919

Enrollment

Registered

2019-07-30

Start date

2016-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with differentiated thyroid cancer

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Have the capacity to understand and willingness to sign an informed consent form 2. Planned for total thyroidectomy because of differentiated thyroid cancer 3. Aged 18-80 years

Exclusion criteria

Exclusion criteria: 1. Alcohol abuse 2. Other malignancy 3. Clinically relevant active systemic disease (such as autoimmune or infectious diseases) 4. Pregnancy 5. Use drugs interfering with thyroid hormone metabolism (e.g. antiepileptic drugs, amiodarone, and lithium) 6. Other primary thyroid disease

Design outcomes

Primary

Measure	Time frame
Epigenetic DNA modifications	—

Contacts

Public ContactAnneke Hokke

Erasmus MC

schildkliercentrum@erasmusmc.nl0031107044986

Outcome results