Migraine/Migraine Iontophoresis/Iontoforese CGRP Propranolol
Conditions
Interventions
Administration of propranolol
Sponsors
Dr. A.H. van den Meiracker,
Internist, Vascular Medicine.
Erasmus Medical Center Rotterdam
‘s Gravendijkwal 230, 3015GC Rotterdam, The
Netherlands
Telephone number : 0031 010 7034220
Fax number : 0031 010 7034937
E-mail: a.vandenmeiracker@erasmusmc.nl
Eligibility
Inclusion criteria
Inclusion criteria: Age between 18 and 64 years Male or female Females should use an oral contraceptive pill (the measurements will be held during any moment of the month, except during the week without pill) or Mirena Non-smoking for > 6 months Body mass index between 19 and 28 kg/m2 Capable and willing to give informed consent General good health, based on medical history and physical examination
Exclusion criteria
Exclusion criteria: History of cardiovascular disease History of migraine Previous history of asthma or use of bronchodilators. Blood pressure <110 systolic (sitting) Heart rate <60 bpm Perimenopausal status of females Any serious illness that can compromise study participation Use of any medication (e.g., NSAIDs, other analgesics) < 48 hrs before the study Dermal diseases at the upper frontal side of the face Pregnancy or breastfeeding History of sensitivity to the fruits of capsicum plants (e.g. chilli peppers) Alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in forehead dermal blood flow | — |
Secondary
| Measure | Time frame |
|---|---|
| change in heart rate change in blood pressure bloodlevels of propranolol | — |
Contacts
Public ContactJ. Langendonk
Erasmus Medical Center Rotterdam
Outcome results
None listed