Aortic valve stenosis and coronary artery disease
Conditions
Interventions
TAVI only
Sponsors
Not applicable (funding by ZonMW)
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1. Symptomatic severe aortic valve stenosis meeting the criteria stated by the ESC; 2. TAVI recommended by multidisciplinary Heart Team; 3. Significant coronary artery disease: = 1 stenosis in epicardial coronary artery (> 2.5mm) or bypass graft. Stenosis is considered significant if angiographic 70-99% or angiographic 40-70% with positive hemodynamic parameters
Exclusion criteria
Exclusion criteria: 1. LM-stenosis or equivalent 2. CAD with patent bypass grafts 3. Contraindication for DAPT 4. Life expectancy < 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite of all-cause mortality, myocardial infarction, stroke and major bleeding after 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Several at different endpoints (4-12 months, total follow up 5 years): all-cause mortality, myocardial infarction, stroke, major and minor bleeding, urgent and elective revascularization, rehospitalization, anginal status, QoL, cost-effectiveness, LV-function. | — |
Contacts
Public ContactM Voskuil
UMC Utrecht
Outcome results
None listed