FLUID MANAGEMENT TARGETED ON DIFFERENT VARIABLES OF PERIPHERAL PERFUSION IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT.

PERIPHERAL PERFUSION TARGETED FLUID MANAGEMENT (PPTFM) IN CRITICALLY ILL PATIENTS: A PILOT STUDY.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20877

Enrollment

Registered

2011-07-07

Start date

2011-08-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral perfusion, fluid management, critically ill patients, intensive care unit. Perifere perfusie, vochttoediening, kritisch zieke patienten, intensive care.

Interventions

Overall, monitoring will be similar for the intervention and the control group. Parameters of peripheral perfusion will be monitored in both groups (techniques to monitor peripheral perfusion are de

Eligibility

Inclusion criteria

Inclusion criteria: All adult (age > 18 years) patients admitted to the Intensive Care Unit with: 1. Hemodynamic instability due to severe sepsis; 2. A mean arterial pressure 3.0 mmol/L.

Exclusion criteria

Exclusion criteria: 1. Moribund; 2. Severe coagulation disorder (contraindication for central venous catheter placement); 3. Severe peripheral vascular disease (interfering with peripheral perfusion measurement).

Design outcomes

Primary

Measure	Time frame
1. Daily fluid balance; 2. Total fluid balance over Intensive Care Unit admission period.	—

Secondary

Measure	Time frame
1. Parameters of peripheral perfusion: A. Capillary refill time; B. Peripheral flow index; C. Forearm skin temperature difference; D. Tissue oxygen saturation. 2. Systemic hemodynamic parameters: A. Mean arterial blood pressure; B. Central venous pressure; C. Central venous hemoglobin oxygen saturation; D. Cardiac output and stroke volume. 3. Respiratory function: A. Arterial oxygen pressure/inspired oxygen fraction ratio (PaO2/FiO2 ratio); B. Duration of mechanical ventilation.	—

Measure

Time frame

1. Parameters of peripheral perfusion: A. Capillary refill time; B. Peripheral flow index; C. Forearm skin temperature difference; D. Tissue oxygen saturation. 2. Systemic hemodynamic parameters: A. Mean arterial blood pressure; B. Central venous pressure; C. Central venous hemoglobin oxygen saturation; D. Cardiac output and stroke volume. 3. Respiratory function: A. Arterial oxygen pressure/inspired oxygen fraction ratio (PaO2/FiO2 ratio); B. Duration of mechanical ventilation.

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Contacts

Public ContactJasper Bommel, van

PO Box 2040

j.vanbommel@erasmusmc.nl+31 (0)10 7040704

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)