diabetes type 1 Artificial pancreas closed loop glucagon kunstalvleesklier
Conditions
Interventions
Open loop (insulin pump treatment) is compared to closed loop.
10 patients attend the CRC. In open loop, the patients will be responsible for the glucose control during postprandial breakfast, post e
Sponsors
AMC Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diabetes mellitus type 1 treated with CSII for a minimum of 6 months; 2. Age: 18-75; 3. Willing and able to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. BMI > 35 kg/m2; 2. HbA1c > 11.0%; 3. Use of heparin, coumarin derivatives or oral corticosteroids; 4. Skin condition prohibiting needle insertion; 5. Pregnancy and/or breastfeeding; 6. Any condition that the local investigator feels would interfere with trial participation or the evaluation of results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Difference in postprandial and post exercise venous glucose excursions measured as area under the curve comparing closed loop format to usual care; 2. Difference in postprandial and post exercise sensor glucose excursions measured as area under the curve comparing closed loop format to usual care. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Difference in the proportion of time spent in euglycaemia (glucose 4.0 – 7.0 mmol/l) comparing the closed loop format to usual care; 2. Difference in numbers of hypoglycaemias (glucose at or below 3.9 mmol/l) comparing the closed loop format to usual care. | — |
Contacts
Public ContactA.C. Bon, van
AMC Amsterdam Meibergdreef 9
Outcome results
None listed