Depression in MS: The effectiveness of web-based self-help treatment.

Depresison in MS: The effectiveness of web-based self-help treatment.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20843

Enrollment

166

Registered

2011-02-21

Start date

2011-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

English: Depression Multiple sclerosis (MS) Problem Solving Therapy (PST) Internet-based treatment Beck Depression Inventory Nederlands: Depressie Multiple Scleroses (MS) Problem Solving Therapie Internet therapie Beck Depression Inventory

Interventions

Problem Solving Therapy: The online cognitive-behavioural self-help treatment examined in this study is based on what is known as ‘problem-solving therapy’ (PST). PST, comprising a cognitive behaviou

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Eligibility

Inclusion criteria

Inclusion criteria: 1. 18 years or older; 2. Score 16 or higher on the Beck Depression Inventory (BDI); 3. Report a diagnosis of definite MS confirmed by a neurologist more than 3 months ago. Potential patients will be excluded if they are currently following psychotherapy, do not have excess to the Internet, have insufficient command of the Dutch language or report suicidal ideation. The latter group of patients will be contacted by telephone and referred to their general practitioner.

Exclusion criteria

Exclusion criteria: 1. No access to Internet or no email-address; 2. No experience with Internet; 3. No sufficient command of Dutch; 4. Unable to read; 5. Current use of antidepressants or other treatment of depression; 6. Current suicidal ideation.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure of this study is depressive symptoms. The Beck Depression Inventory (BDI) is a self-report instrument for assessing the existence and severity of depressive symptoms and is the most commonly used measure of depression severity in patients with MS. The Beck Depression Inventory Second Edition (BDI-II) is the most recent version of the BDI. Each of the 21 items match a symptom of depression according to the DSM-IV (DSM-IV, 1994). The total score is calculated by adding all the items and lies in between 0 and 63. The sum of the scores indicates the severity of the depression. Scores of 0 to 13 represent minimal depressive symptoms, scores from 14 to 19 indicate mild depression, scores from 20 to 28 moderate depression and scores of 29 to 63 indicate severe depression. The BDI has shown to be reliable, valid and responsive, and has been widely used in research on MS patients.	—

Measure

Time frame

The primary outcome measure of this study is depressive symptoms. The Beck Depression Inventory (BDI) is a self-report instrument for assessing the existence and severity of depressive symptoms and is the most commonly used measure of depression severity in patients with MS. The Beck Depression Inventory Second Edition (BDI-II) is the most recent version of the BDI. Each of the 21 items match a symptom of depression according to the DSM-IV (DSM-IV, 1994). The total score is calculated by adding all the items and lies in between 0 and 63. The sum of the scores indicates the severity of the depression. Scores of 0 to 13 represent minimal depressive symptoms, scores from 14 to 19 indicate mild depression, scores from 20 to 28 moderate depression and scores of 29 to 63 indicate severe depression. The BDI has shown to be reliable, valid and responsive, and has been widely used in research on MS patients.

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Secondary

Measure	Time frame
Secondary outcomes include other measures of depression, problem solving skills, quality of life, disability level, well-being, social support, suicide ideation, fatigue, anxiety, mastery and satisfaction. Measurements: 1. Depression: Beck Depression Inventory and Inventory (BDI) of Depressive Symptomatology (IDS); 2. Anxiety: Beck Anxiety Inventory (BAI), Hospital Anxiety and Depression Scale (HADS); 3. Quality of life: The EuroQol consists of the EQ-5D and EQ-VAS; 4. Well-being is further measured with the WHO-5 wellbeing index (WHO-5); 5. Impact of MS and disability level is measured by the Multiple Sclerosis Impact Scale (MSIS-29). Disability level is also measured by the Expanded Disability Status Scale (EDSS), assessed by telephone; 6. Fatigue: The Fatigue Severity Scale (FSS) is a 9-item scale, used to assess the severity of fatigue; 7. Cognition: The Multiple Sclerosis neuropsychological questionnaire (MSNQ) is a self-report screening measure of neuropsychological functioning in MS; 8. Problem solving skills: The Social Problem Solving Inventory - Revised (SPSI-R) contains 52 items and determines individual problem-solving skills. The scales ‘avoidance style’ (AS) (7 items), ’negative problem orientation (NPO, 10 items) and positive problem orientation’ (PPO, 5 items) will be used; 9. Mastery: The 5-item Pearlin and Schooler Mastery Scale. Social support: The Social Support Inventory contains questions on details about social support from the four most intimate persons; 10. Satisfaction: The Client Satisfaction Questionnaire (CSQ-8) measures patient satisfaction with the intervention; 11. Interview (pre-test only): Patients who score above the cut-off score of 16 on the BDI are invited for a structured clinical interview for presence of depression and anxiety disorders and suicidal ideation (World Health Organiszation (WHO) version 2.1). The CIDI establishes diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Ed	—

Measure

Time frame

Secondary outcomes include other measures of depression, problem solving skills, quality of life, disability level, well-being, social support, suicide ideation, fatigue, anxiety, mastery and satisfaction. Measurements: 1. Depression: Beck Depression Inventory and Inventory (BDI) of Depressive Symptomatology (IDS); 2. Anxiety: Beck Anxiety Inventory (BAI), Hospital Anxiety and Depression Scale (HADS); 3. Quality of life: The EuroQol consists of the EQ-5D and EQ-VAS; 4. Well-being is further measured with the WHO-5 wellbeing index (WHO-5); 5. Impact of MS and disability level is measured by the Multiple Sclerosis Impact Scale (MSIS-29). Disability level is also measured by the Expanded Disability Status Scale (EDSS), assessed by telephone; 6. Fatigue: The Fatigue Severity Scale (FSS) is a 9-item scale, used to assess the severity of fatigue; 7. Cognition: The Multiple Sclerosis neuropsychological questionnaire (MSNQ) is a self-report screening measure of neuropsychological functioning in MS; 8. Problem solving skills: The Social Problem Solving Inventory - Revised (SPSI-R) contains 52 items and determines individual problem-solving skills. The scales ‘avoidance style’ (AS) (7 items), ’negative problem orientation (NPO, 10 items) and positive problem orientation’ (PPO, 5 items) will be used; 9. Mastery: The 5-item Pearlin and Schooler Mastery Scale. Social support: The Social Support Inventory contains questions on details about social support from the four most intimate persons; 10. Satisfaction: The Client Satisfaction Questionnaire (CSQ-8) measures patient satisfaction with the intervention; 11. Interview (pre-test only): Patients who score above the cut-off score of 16 on the BDI are invited for a structured clinical interview for presence of depression and anxiety disorders and suicidal ideation (World Health Organiszation (WHO) version 2.1). The CIDI establishes diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Ed

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Contacts

Public ContactR.E. Boeschoten

GGZinGeest / VU Medical Center Academic Anxiety Outpatient Clinic A. J. Ernststraat 1187

r.boeschoten@ggzingeest.nl+31 (0)20 7884659

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)