colorectal cancer, screening, darmkanker
Conditions
Interventions
People will receive two identical FITs (OC-sensor, Eiken Japan) to sample from two consecutive bowel movements.
Sponsors
Erasmus Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Average risk persons aged 50-75 years old in the Rotterdam-Rijnmond region. We will invite all persons from the dynamic cohort of approximately 3200 persons that were invited in the previous rounds and were originally recruited by random selection in the city population database (Gemeentelijke Basis Administratie, GBA).
Exclusion criteria
Exclusion criteria: Exclusion criteria for colonoscopy are: complete colonoscopy or CT-colonography performed within the last 2 years; severe co-morbidity (ASA IV/V); terminal disease (life-expectancy < 5 years); inability or refusal to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Participation, positivity rate, diagnostic yield of two-sample FIT screening. | — |
Secondary
| Measure | Time frame |
|---|---|
| Participation-rate and diagnostic yield of a 4th round of biennial two-sample FIT-screening compared to previous rounds. Impact of repeated biennial two-sample FIT-screening on participation-rates (per round, in consecutive rounds and per program), as well as the yield and occurrence of interval cancers in participants and non-participants of repeated rounds. Comparison of outcomes with paralell one-sample FIT screening cohort. | — |
Contacts
Public ContactM.C.W. Spaander
Erasmus Medical Center Rotterdam
Outcome results
None listed