Hypertension - hypertensie Obesity - obesitas Microcirculation - microcirculatie
Conditions
Interventions
The hypertensive subjects will be asked to discontinu the intake of antihypertensive medication 3 weeks prior to the study.
All subjects will be asked to collect urine during 24hrs prior to the first
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: - Inclusion criteria healthy normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure 140/90mmHg.
Exclusion criteria
Exclusion criteria: - Exclusion criteria for healthy normotensive and hypertensive subjects: 1. Obesity (BMI>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use >4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses - Exclusion criteria for normotensive obese subjects: 1. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 2. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 3. Smoking 4. Alcohol use >4U/day 5. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 6. Pregnancy 7. Wearing contact lenses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Functional recruitment of capillaries in the skin. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Perfused capillary density in the nailfold. - Endothelium- (in)dependent vasodilatation of finger skin microcirculation - Density of arterioles, capillaries and venules in the bulbar conjunctiva. - Diameter of arterioles and venules in the bulbar conjunctiva. - Insulin sensitivity (HOMA-IR) | — |
Contacts
Public ContactA.J.H.M. Houben
Department of Internal Medicine University Hospital Maastricht P.O. Box 5800
Outcome results
None listed