Hip fracture
Conditions
Interventions
None
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1) Written informed consent; 2) Recent (<24 h before admission to the hospital) femoral bone fracture requiring hip replacement surgery; 3) Admitted to MUMC+ to receive a femoral head-neck prosthesis or total hip replacement.
Exclusion criteria
Exclusion criteria: 1) Physical restlessness due to delirium; 2) Rheumatoid arthritis; 3) Chemotherapy or radiotherapy; 4) (Multiple) Myeloma or other primary cancer tumor with possible bone metastasis;)5) Collagen disorders, e.g. Marfan and Ehler-Danlos; 6) Any other medical condition that may interfere with the safety of the subjects or the outcome parameters, in the investigators judgement; 7) Investigator’s uncertainty about the willingness or ability of the subject to comply with the protocol instructions; 8) Participation in any other studies involving investigational or marketed products concomitantly to entry into the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone protein synthesis rates in the femoral shaft and femoral head tissue, expressed in FSR (%/h) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters are tissue-specific protein synthesis rates in femoral bone, femoral head cartilage, hip synovium, and m. gluteus maximus, expressed in FSR (%/h). | — |
Contacts
Public ContactFloris Hendriks
Maastricht University Medical Centre+ / NUTRIM School of Nutrition and Translational Research in Metabolism / Department of Human Biology
Outcome results
None listed