Breath analysis
Conditions
Interventions
This is a diagnostic multicentre cross-sectional observational proof of concept study. Included patients will have been intubated and mechanically ventilated for at least 48 hours (based on the defini
Sponsors
Academic Medical Centre, Amsterdam, the Netherlands; and University Hospital South Manchester NHS Foundation Trust, United Kingdom
Eligibility
Inclusion criteria
Inclusion criteria: 1. 18 years and older 2. Intubated and mechanically ventilated for >48 hours 3. Suspected for ventilator associated pneumonia (VAP) Definition of suspected VAP: start of antibiotics for a suspected lower respiratory infection in a patient that has been on mechanical ventilation for more than 48h
Exclusion criteria
Exclusion criteria: 1. Patients receiving end of life care 2. Patients where there is clinical suspicion of highly infectious disease (patients in strict isolation such as Middle East Respiratory Syndrome, Ebola or resistant tuberculosis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combination of volatile markers that gives an accurate discrimination between patients that are suspected of VAP who have positive cultures and who have negative cultures with a sensitivity of at least 99%. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Molecular markers that can distinguish between patients with and without microbiologically confirmed VAP with p <0.05 and a false discovery rate < 0.05. 2) Molecular markers that can distinguish between patients with and without specific pathogens with p <0.05 and a false discovery rate < 0.05. 3) Accuracy of discrimination within the subgroup of patients with and without a previous respiratory infection. 4) Accuracy of discrimination within the subgroup of patients intubated for less and more than one week. | — |
Contacts
Public ContactTamara Nijssen
Philips Research
Outcome results
None listed