Single- or Multiple-occupancy room isolation of patients colonised with ESBL-producing Enterobacteriaceae.

Single- or Multiple-occupancy room isolation of patients colonised with ESBL-producing Enterobacteriaceae: A multicentre cluster-randomised study (SoM-study).

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20768

Enrollment

592

Registered

2011-03-04

Start date

2011-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antimicrobial resistance Infection prevention Nosocomial infection

Interventions

1. Contact isolation on a single-occupancy room

2. Contact isolation on a multiple-occupancy room.

Eligibility

Inclusion criteria

Inclusion criteria: Patients that are hospitalised on a non-ICU, non-hemato-oncology, non-transplantation ward, and are colonised or infected with ESBL-producing Enterobacteriaceae.

Exclusion criteria

Exclusion criteria: 1. Patients with an age of less than 18 years; 2. Patients who refuse or are unable to give permission for using patient-specific data; 3. Patients that are known to be colonised or infected with a microorganism that requires isolation in a single room, e.g. highly resistant Acinetobacter spp., highly resistant Streptocococcus pneumoniae, highly resistant Enterococcus faecium, MRSA, and (multiresistant) Mycobacterium tuberculosis; 4. Patients that are colonised or infected with ESBL-producing Enterobacteriaceae of the same* species and with the same antibiogram as that of an isolate that has been detected previously in clinical cultures of previously included index patients or ward mates that are at that moment still hospitalised on the same ward.

Design outcomes

Primary

Measure	Time frame
The transmission rate of ESBL-producing Enterobacteriaceae, i.e. the proportion of index patients in which transmission of ESBL-producing Enterobacteriaceae to a ward mate occurs.	—

Secondary

Measure	Time frame
1. The transmission rate of mobile genetic elements harbouring resistance genes that encode for ESBL, i.e. the proportion of index patients in which transmission of mobile genetic elements to a ward mate occurs; 2. The occurrence of ESBL-producing Enterobacteriaceae in clinical cultures from hospitalised patients; 3. The prevalence of colonisation with ESBL-producing Enterobacteriaceae in hospitalised patients; 4. All-cause mortality at 28 days and after 6 months.	—

Measure

Time frame

1. The transmission rate of mobile genetic elements harbouring resistance genes that encode for ESBL, i.e. the proportion of index patients in which transmission of mobile genetic elements to a ward mate occurs; 2. The occurrence of ESBL-producing Enterobacteriaceae in clinical cultures from hospitalised patients; 3. The prevalence of colonisation with ESBL-producing Enterobacteriaceae in hospitalised patients; 4. All-cause mortality at 28 days and after 6 months.

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Contacts

Public ContactM.F.Q. Kluytmans - Bergh, van den

Amphia Hospital, location Molengracht / PObox 90158

marjoleinkluytmans@gmail.com+31 (0)76 5953015

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)