obesity, nutrient sensing, obesitas, nutrient perceptie
Conditions
Interventions
The subjects receive in the duodenal as well as in the ileal study:
- an oral glucose drink in the morning and in the evening
- an infusion with glucose in the duodenum or ileum, in the morning and
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy male or female 2. Age 18-55 years 3. Body Mass Index (BMI) of 18-29 kg/m2
Exclusion criteria
Exclusion criteria: 1. Evidence of severe diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. 2. Gastrointestinal or hepatic disorders influencing gastrointestinal absorption or transit. 3. Use of psychotropic drugs. 4. Use of alcohol in excess of 21 units/week for males and 14 units/week for females. 5. Concomitant medication that can increase gastric pH, or alter gastric emptying, or alter intestinal transit, or influence satiety/energy intake. 6. Pregnancy, lactation, wish to become pregnant during study, or having a positive pregnancy test at inclusion. 7. Reported unexplained weight loss/gain of more than 2 kg in the month before the study enrollment. 8. Score > 9 on Factor 1 (dietary restrained) of the Dutch translation of the Three Factor eating Questionnaire (TFEQ). 9. Blood donations less than three months previous to study enrollment. 10. One or more of the following dietary habits: medically prescribed diets, weight reduction diets, or vegetarian/macrobiotic/biologically dynamic food habits. 11. Reported working on late/night shifts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endpoints of the research are differences in satiety, food intake, and changes in hormone concentrations between the conditions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences between conditions in thirst or nausea. | — |
Contacts
Public ContactAstrid Smeets
Maastricht University PO Box 616
Outcome results
None listed