regular physiology
Conditions
Interventions
sucralose sweetened beverages containing maltodextrin
Sponsors
Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: • Right handed • Age 18 – 35yr • BMI 18.5 - 25 kg/m2 • Being healthy (self-reported) • Having given written informed consent (see E2)
Exclusion criteria
Exclusion criteria: • Drug use or medical conditions which may interfere with normal functioning of the digestive tract • Drug use or medical conditions which may interfere with normal functioning of the circulatory system • Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions) • Food allergy to or unwillingness to consume maltodextrin, sucralose of food flavourings • Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening • Personnel of Wageningen University, department of Human Nutrition • Current participation in other research from the Division of Human Nutrition Please see form F1 for full exclusion questionnaire • Having a contra-indication to MRI scanning (including, but not limited to):  Pacemakers and defibrillators  Intraorbital or intraocular metallic fragments  Ferromagnetic implants  Claustrofobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment induced changes from baseline: •Change in resting energy expenditure in kcal/day •Change in gastric emptying rate in mm3/min •Change in cerebral blood flow in mL/100 g·min | — |
Secondary
| Measure | Time frame |
|---|---|
| Internal state (appetite) ratings before and after treatment Pleasantness ratings of beverages after treatment | — |
Contacts
Public ContactGuido Camps
Postbus 17
Outcome results
None listed