Influence of long term administration of fluoxetine on cerebral threshold and muscle activation patterns in chronic stroke.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20685

Enrollment

Registered

2006-09-19

Start date

2007-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

20 mg of fluoxetine during 12 weeks

Eligibility

Inclusion criteria

Inclusion criteria: Chronic ischemic stroke patients (> 6 months after stroke); age > 18

Exclusion criteria

Exclusion criteria: 1. Patients suffering from another neurological disease; 2. uncompensated hemineglect or cognitive disabilities; 3. epilepsy, or first epileptic insult post stroke; 4. patients with first grade relatives suffering from epilepsy; 5. pregnancy; 6. pacemaker; 7. pathological heart rhythms disorders; 8. use of antidepressants

Design outcomes

Primary

Measure	Time frame
excitability of the primary motor area, measured by motor threshold and stimulus response curve; muscle activation, measured by calculating RMS during isometric and dynamic movements	—

Secondary

Measure	Time frame
brain activation patterns; phase synchronization of the brain; motor function	—

Contacts

Public ContactH.I. Genderen, van

Roessingh Research and Development Rehabilitation Centre P.O. Box 310

h.vangenderen@rrd.nl+31 (0)53 4875765

Outcome results