Amyotrophic Lateral Sclerosis, Quality of life, Cognitive Behavioural Therapy, Aerobic Exercise therapy, Neuromuscular diseases. Amyotrofische Lateraal Sclerose (ALS), Kwaliteit van Leven, Cognitieve GedragsTherapie, Aerobe Fysieke Training, NeuroMusculaire Ziektes
Conditions
Interventions
(Exp. group 1) AET + usual care. AET consists of aerobic exercises for a period of 16 weeks, 3 days a week, twice at home and once a week in an individually guided group session in a hospital or rehab
Sponsors
University Medical Centre Utrecht, Department of Rehabilitation
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 70 years; 2. A life-expectancy longer than one year; 3. Forced Vital Capacity at least 80%; 4. Diagnosis of "Probable" of "definite" ALS according to the "revised El Escorial WFN criteria"; 5. At least 3 months post-diagnosis ALS; 6. Being in the rehabilitation phase; diagnotic phase is completed; 7. Walking-ability with or without a ankle-foot orthotic or stick and cycling-ability on a bicycle ergometer, in that capacity that the intervention is expected to be completed.
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment; 2. Insufficient mastery of the Dutch language; 3. Disabling co-morbidity interfering with the intervention programs or influencing outcome parameters (including severe cardiopulmonair disease, like chest pain, arrhytmia, pacemaker, cardiac surgery, sever dyspnoea d'effort or emphysema, epileptic seizures, poorly regulted diabetes mellitus or hypertension; 4. Psychological disorder, in that capacity that the intervention could not be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Life and activities. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Functional capacity of the patient: cardiorespiratory fitness, strength endurance of the quadriceps, isokinetic muscle strength of the quadriceps, lung function, functional tests, fatigue and pain; 2. Cognitive behavioural aspects of the patient: coping, illness cogitions, personality, mood, impact of event, competences, social suppport; 3. Partner of the patient: quality of life, coping, mood, caregiver strain. | — |
Contacts
Public ContactA.C. Groenestijn, van
Revalidatiecentrum De Hoogstraat Rembrandtkade 10
Outcome results
None listed