Lung cancer, re-irradiation, thorax
Conditions
Interventions
Radiotherapy
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: • Cytological or histological proof of the current tumor: NSCLC or large cell lung cancer with neuro-endocrine differentiation; • Current tumor located close (5 cm or less) to the high dose region (50 Gy EQD2 or more) of the previous radiation; • Interval between initial treatment with curative intent and reirradiation is ≥9 months; • Age ≥ 18 years; • If woman of childbearing potential: use of adequate contraceptive precautions; • Written informed consent; • FEV1 > 40% of predicted; • Karnofsky score ≥ 70; • Treatment in radical setting (at least 45 Gy EQD2) is possible according to the local investigator; • Staging of recurrent lung cancer is performed with a whole body CT scan and PET scan; • Treatment options for the patient will be discussed at multidisciplinary oncology board.
Exclusion criteria
Exclusion criteria: • Pregnancy; • Inability to retrieve the previous radiation fields, total dose, dose per fraction and time of first radiation series and DVH of the organs at risk; • Contraindication to use intravenous CT contrast; • The use of radiosensitizers such as plaquenil; • Patients with more than 3 (oligo)metastases and/or (oligo)metastasis in more than 2 organs and/or (oligo)metastasis which cannot be treated locally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | — |
Secondary
| Measure | Time frame |
|---|---|
| - Local control - Disease-free survival - Acute and late toxicity - Cumulative dose to the organs at risk - Quality of life | — |
Contacts
Public ContactM. Duijm
Outcome results
None listed