hypoxia, pulmonary hypertension, COPD, diabetes,
Conditions
Interventions
Crossover trial, with randomly a hyperglycaemic (15 mmol/l) hypoxic episode of 60 minutes and a normoglycaemic hypoxic episode of 60 minutes. Hyperglycaemia accomplished according the glucose clamp te
Sponsors
LUMC
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers aged 18-45 with echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI > 30); 2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes; 3. Presence of psychiatric disease; 4. History of chronic alcohol or drug use; 5. Possibility of pregnancy; 6. Lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Ventilatory response: We will monitor ventilation continuously and afterwards analyze these data based on acute response as well as non linear modeling; 2. Pulmonary arterial pressure will be estimated using the tricuspid valve maximum gradient, which is a good estimate of the systolic pulmonary arterial pressure, using echocardiography. We will monitor the PAP every minute for the first 20 minutes and thereafter every 5 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital and echocardiographic parameters. | — |
Contacts
Public ContactRob Lindeman
Department of Anesthesiology LUMC, P5-Q
Outcome results
None listed