The participants to this study are healthy adults.
Conditions
Interventions
None listed
Sponsors
University of Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - Having participated in the study ‘Age and performance: the relation between brain structure and cognition’. - Right-handed - Normal (or corrected to normal) vision
Exclusion criteria
Exclusion criteria: Not matching any of the inclusion criteria, as well as matching any criterion in the MRI exclusion list, including, but not limited to, claustrophobia, infarctions, epilepsy or family history of epilepsy, presence of metal inside the body, presence of electric/electronic devices inside the body (pacemakers, etc.), and presence of intracardial lines. We will exclude users of non-removable dentures, psychoactive medication, including antidepressants, anxiolytic, and anti-epileptic drugs, as well as cannabis, XTC or other recreational drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive measures: Number of words remembered (15 word test), variable representing the Simon effect for inhibition (Simon task), completion time (TMT). Imaging measures as derived from MRI scans: Whole brain grey matter volume, cortical thickness in the superior frontal gyrus, FA of the prefrontal cortex | — |
Secondary
| Measure | Time frame |
|---|---|
| Main study parameters of cognitive performance consist of the default outcome measures of each cognitive task. Regarding the MRI scans we derive volumetric data of grey matter, white matter and cerebral spinal fluid,(mean) cortical thickness, percentage of white matter hyperintensities in relation to brain volume, and DTI scalar values (FA, MD, AD and RD). Standardized change scores of these measures will be calculated.Further more information on reduction of working hours and possible retirement will be taken into consideration. | — |
Contacts
Public ContactTineke de Haan
University of Groningen
Outcome results
None listed