Fatigue, caffeine, vermoeidheid, cafeine
Conditions
Interventions
All participants will be tested twice: once after acute caffeinated coffee administration (100 mg caffeine, equivalent to 1 cup of coffee) and once after acute decaffeinated coffee administration (pla
Sponsors
Universiteit Maastricht
Eligibility
Inclusion criteria
Inclusion criteria: Only right handed physically and mentally healthy volunteers will be included. 1. Male; 2. Moderate caffeine consumers; 3. School teachers.
Exclusion criteria
Exclusion criteria: The exclusion criteria are based on factors which are MRI contraindications or are known to affect neuropsychological task performance, brain activity, caffeine pharmacokinetics or the safety of caffeine consumption. People who suffer from significant past or present physical or psychiatric illnesses (epilepsy, stroke, Parkinson’s disease, MS, brain surgery, brain trauma, electroshock therapy, kidney dialysis, renal dysfunction, treatment by a neurologist or psychiatrist, diabetes, heart disease, migraine, Ménière’s disease, hypertension, cardiac arrhythmias, heart palpitations, brain infections, chronic fatigue syndrome or burnout, impaired liver function, peptic ulcer disease), who currently habitually consume nicotine at any time during weekdays (due to the effect of smoking on caffeine metabolism (Nehlig, 1999) or have drug or alcohol problems, who receive medication at the moment of inclusion (in particular disulfiram, mexiletine, cimetidine, norfloxacin, enoxacin, ciprofloxacin, nonsteroidal anti-inflammatory drugs, aspirin, corticosteroids, phenylpropanolamine, monoamine oxidase inhibitors, antiarrhythmic agents and diazepam), who have an MRI contraindication (brain surgery, pacemaker, metal objects/part in body, claustrophobia, large parts of the body tattooed) or who are hypersensitive to caffeine, will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome measures are subjective fatigue and vitality ratings, neuropsychological performance (mean reaction time and accuracy) and the fMRI blood oxygen level dependent (BOLD) response during working memory and verbal learning tasks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are the concentration of caffeine in saliva throughout the test sessions and blood glucose levels at the beginning of the test session. | — |
Contacts
Public ContactE. Klaassen
Department Psychiatry and Neuropsychology Maastricht University Postbus 616
Outcome results
None listed