Heart failure
Conditions
Interventions
Invasive and non-invasive volume measurements
Sponsors
VUmc
Eligibility
Inclusion criteria
Inclusion criteria: Patients need to fulfil the 2013 guideline of the European Society of Cardiology criteria for cardiac pacing and cardiac resynchronisation therapy upon receiving a CRT.
Exclusion criteria
Exclusion criteria: - Age 300 ml - Other implantable devices than CRT/PM/ICD in the upper body - Structural anatomical / congenital cardiac “deviations”
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to assess clinical feasibility and accuracy of HCP measurements in CRT patients during different pacing settings. We will evaluate the accuracy of LV volumetric measurements by comparing volume-time curves obtained using HCP with the conductance catheter (gold standard) measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Evaluate derivatives of volume-time curves (i.e. stroke volume, max volume, min volume, 1/3 FFR) and compare these derivatives between different pacing settings and between the HCP volume-time curve and conductance catheter volume-time curve. 2. Assessment of pressure data during different pacing settings and comparison between the invasive pressure measurements (conductance catheter) and the non-invasive pressure measurements (Nexfin). 3. Reconstruction of pressure-volume (PV) loops with Nexfin and HCP data and compare these PV- loops with PV-loops obtained using the conductance catheter. | — |
Contacts
Public ContactLuuk Hopman
VUmc
Outcome results
None listed