Venous thrombosis, gut microbiome, antibiotics, coagulation, complement, obesity.
Conditions
Interventions
Orally applied Vancomycin 500mg 3 times daily for 7 days.
Sponsors
The Arctic University of Norway, Tromsø, department of Clinical Medicine, TREC (Thrombosis Research and Expertise Center), Farmasibygget, 9037 Tromsø, Norge.
Eligibility
Inclusion criteria
Inclusion criteria: - Eighteen years of age or older - Not older than 40 years - Comprehension of English or Norwegian language - Lean bodymass (n=20) - BMI >=27kg/m2, (n=20)
Exclusion criteria
Exclusion criteria: - The use of any medication during the last month before the start of the study until the end of the study period (including oral contraceptives) - Being post-partum or having used the contraceptive pill during the last 3 months before the study - The use of anti-, probiotics (Idoform Classic Plus) in the 2 months before the study - Pregnancy in women (a pregnancy test will be offered to all participating women) - Known chronic medical inflammatory conditions including inflammatory bowel diseases, rheumatic diseases, diabetes mellitus and HIV-infection - Recent history of illness 2x upper limit of normal - Any current feverish episode at day -7 (T>37.5 degrees Celsius)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Factor VIII (FVIII:C) | — |
Secondary
| Measure | Time frame |
|---|---|
| Individual coagulation parameters Parameters of inflammation (hs-CRP, TNF-alpha) Lipopolysaccharids in plasma Complement activity Changes in composition of the gut microbiome | — |
Contacts
Public ContactVladimir Tichelaar
UMC Groningen - Hematologie - HP AA24
Outcome results
None listed