Coronary artery disease, heart failure. Coronair lijden, hartfalen.
Conditions
Interventions
Our patients will be given enteral nutrition (n=16), peripheral parenteral nutrition (n=16) or a saline solution (control) (n=16) at least three days before, during, and one day after CABG. Both enter
Sponsors
Academic Medical Center University of Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients who have to undergo an off-pump coronary artery bypass grafting (CABG) operation; 2. Aged 18 till 81 years.
Exclusion criteria
Exclusion criteria: 1. Combined valve and CABG procedures; 2. Aged 80 years; 3. Diabetes mellitus type I; 4. Pregnancy; 5. Renal insufficiency defined as creatinine > 95 micromol/L for women and > 110 micromol/L for men; 6. Liver insufficiency defined as alanine aminotransferase > 34 U/I for women and > 45 U/I for men.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcomes are concentrations of amino acids, and methylated arginines in blood plasma and cardiac tissue, and cardiomyocytes functioning assessed by histology. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study outcomes are cardiac perfusion, and cardiac fatty acid and glucose metabolism, measured by myocardial scintigraphy and positron emission tomography. | — |
Contacts
Public ContactB.A.J.M. Mol, de
P.O. Box 22700
Outcome results
None listed