Critical illness in general
Conditions
Interventions
None
Sponsors
Erasmus MC - Sophia Children's Hospital
Eligibility
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: - All children with an expected PICU-stay of at least two days.
Exclusion criteria
Exclusion criteria: - Preterm, i.e. postconceptional age of <37 weeks, on admission - Syndrome associated with severe mental retardation, except for trisomy 21 - Hydrocortison use in the 3 days prior to admission - Melatonin use within 24 hours prior to admission - Transfer from another PICU or NICU - Weight < 2.0 kg - Expected not to receive arterial line during study period - Previously included in this Critical Clock study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To describe the distributions of rhythmic parameters in the paediatric ICU and their evolution during PICU stay. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To identify the correlations between different circadian rhythm parameters. 2. To construct a robust combined measure of circadian rhythmicity from these parameters. 3. To assess the accuracy of combinations of vital signs in determining underlying circadian rhythm with the constructed measure mentioned in secondary objective 2 as a reference. 4. To determine the association between circadian rhythms in relation with both patient and disease characteristics on one hand and outcome on the other. | — |
Contacts
Public ContactArnout Cramer
Erasmus MC
Outcome results
None listed