The effect of ketamine and methadon on healthy volunteers with special focus on painscore, sedation, ventilatory depression and change of pupil diameter.

Effect of u opioid receptor (MOR) versus N-methyl-D- aspartate(NMDAR) receptor involvement in ketamine and methadone effects in healthy volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20544

Enrollment

Registered

2009-09-30

Start date

2010-01-02

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

analgesia respiratory depression pijnstilling analgesie ademhalingsdepressie

Interventions

There are 2 separate studies. Study A,in which the subject will receive a 80 min infusion of S(+) ketamine and Study B in which the subject will receive iv methadone. Each study has 2 legs, a respira

Eligibility

Inclusion criteria

Inclusion criteria: 48 healthy volunteers of either sex in the range op 18-45 years.

Exclusion criteria

Exclusion criteria: 1. Obesity (BMI>35); 2. Presence of medical disease (heart-,lung-, liver-,kidney-, neurologic disease,diabetes m, pyrosis,diaphragmatic hernia); 3. Presence of psychiatric disease; 4. History of chronic alcohol or illicit drug use; 5. Allergy to study medications; 6. For females we require the use of oral contraceptives.

Design outcomes

Primary

Measure	Time frame
Little is known on the relative contribution of NMDARand u-opioid receptor systhems in the analgesic and side effect profile of methadone and ketamine, therefore we measure respiration, sedationscore (Visual Analog Score), painscore (Visual Analogue Score) and pupildiameter (pupillometry).	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)