Open heart surgery: CABG, heart valve surgery and the combination of both.
Conditions
Interventions
Use of by filtration leukocyte reduced blood transfusions vs use of buffy-coat depleted blood transfusions (=1990's standard in NL).
Sponsors
Leiden University Medical Center;
Red Cross Blood Bank Leidsenhage, Leiden
Eligibility
Inclusion criteria
Inclusion criteria: Patients planned for open heart surgery: CABG, heart valve surgery or the combination of both.
Exclusion criteria
Exclusion criteria: 1. Age < 18 year; 2. Transfusions within last 6 months; 3. Pre-existing medical indication for filtered blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-HLA antibody formation (tested by LCT)and anti-erythrocyte antibody formation (tested in 3 cell panel, with PEG). Samples for analyses are collected before surgery, on day 7 post-surgery, 3-10 weeks post-surgery and 20-30 weeks post-surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Post-operative infections; 2. Hospital stay; 3. ICU-stay; 4. Mortality; 5. Costs-effect-analyses. In combination with other RCTs, that have randomized between these same two blood products: Long term effects on the incidence of autoimmune diseases and malignancies. | — |
Contacts
Public ContactL.M.G. Watering, van de
Sanquin Blood Bank, Southwest region, Plesmanlaan 1a
Outcome results
None listed