Persistent and longstanding persistent atrial fibrillation
Conditions
Interventions
-Catheter ablation
-Surgical ablation
Sponsors
University Medical Center Utrecht (UMCU)
Eligibility
Inclusion criteria
Inclusion criteria: - Patients age is > 18 years - Patients with persistent or longstanding persistent atrial fibrillation. Persistent AF is defined as sustained episodes of atrial fibrillation lasting >7 days. Longstanding persistent AF is defined as sustained episode lasting >1 year. - Patients undergoing a first time invasive treatment procedure for persistent atrial fibrillation - AF must be recorded at least once by ECG, holter, telemetry, loop recorder or internal device. - Patients must give informed consent to participate
Exclusion criteria
Exclusion criteria: - Patients suffering from paroxysmal atrial fibrillation. Paroxysmal AF is defined as episodes of AF that terminates spontaneously within 7 days. - Patients suffering from AF secondary to a reversible cause as electrolyte imbalance or hyperthyroidism. - Body mass index >40 - Active infection or sepsis - Unstable angina, myocardial infarction within the previous 6 months - Patients with any contra-indications for electrophysiologic study and ablation in the left atrium: -pregnancy -presence of a left atrial thrombus - Patients with any contra-indications for video assisted thoracoscopic surgery: - prior lung/cardiac surgery - pleural adhesions - elevated hemidiaphragm - mitral or aortic valve regurgitation above grade 2 - moderate to severe mitral or aortic stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of the study is to evaluate which treatment- surgical ablation or catheter ablation- is most effective in treating persistent and longstanding persistent atrial fibrillation measured by success at 12 months after 1 procedures. | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of periprocedural complications, clinical success after 12 months, procedural duration, number of repeat procedures, success and clinical success after 2 procedure after 12 months, quality of life measurements before and 6 months after the first procedure. | — |
Contacts
Public ContactC. Teunissen
Heidelberglaan 100
Outcome results
None listed