obsessive-compulsive disorder, gambling disorder, repetitive behavior, magnetic resonance imaging (fMRI), compulsivity obsessief-compulsieve stoornis, gokverslaving, controle verlies, kernspintomografie (fMRI), compulsiviteit
Conditions
Interventions
Sponsors
Academicl Medical Center Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: OCD group: • DSM-5 diagnosis of OCD • No other psychiatric disorder • Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 20 • 18-65 years of age • Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements GD group: • DSM- 5 diagnosis for Gambling Disorder • No other psychiatric disorders. • Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements • 18-65 years of age HC group: • No current psychiatric diagnosis no history of OCD or GD. • Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements • 18-65 years of age
Exclusion criteria
Exclusion criteria: All groups: • Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI neurological disorders section • IQ below 80 • insufficient command of the Dutch language • MRI contraindications such as metal implants, claustrophobia, pregnancy • recent (<2 weeks) use of psychotropic medication other than naltrexone (smoking and nicotine dependence is allowed in all groups). • Endocrinological disorders or regular use of corticosteroids • Current treatment with tricyclic antidepressant or antipsychotic medication • Use of other psychotropic medication (apart from SSRI's), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement • Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel). • Pregnancy - Left-handedness OCD group and HC group: scoring lower than 5 on SOGS (gambling severity) questionnaire; hence not suffering from gambling problems. GD and HC group: scoring lower than 5 Y-BOCS; hence not suffering from OCD symptoms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Confidence and brain activation as measured with fMRI during the confidence task • Risk taking and ambiguous behaviour measure with a cognitive task and it’s correlation with confidence task. •Compulsive checking behavior as determined by the checking task | — |
Secondary
| Measure | Time frame |
|---|---|
| • Functional connectivity as measured with fMRI during the resting-state condition • Self-reports of development and experience of compulsions. | — |
Contacts
Public ContactRuth Holst, van
Outcome results
None listed