None listed
Conditions
Interventions
MS-CT coronary angiography: An MS-CT coronary angiogram is performed using a bolus injection of 100 ml contrast agent into a brachial vein.
The scan is made during a breathhold of 20 seconds.
The wh
Antonius Hospital Nieuwegein).
Sponsors
ZonMw NL
Eligibility
Inclusion criteria
Inclusion criteria: Symptomatic patients with stable angina (N=160) and unstable angina (N=160) who are scheduled for diagnostic invasive coronary angiography will be enrolled into the study. In addition these patients also need to fulfill the following inclusion criteria. a) male and female younger than 70 years, b) stable angina pectoris that warrants further evaluation by coronary angiography and revascularization by percutaneous coronary intervention, c) stable heart rhythm, d) heart rate less than 70 b.p.m. (either spontaneous or drug-induced) and e) no contra indications such as severe renal or pulmonary dysfunction or X-ray contrast intolerance.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they are: 1. Older than 70 years; and 2. Have an irregular heart rhythm (predominantly atrial fibrillation); or 3. Have severe renal or pulmonary dysfunction or x-ray contrast intolerance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy in terms of sensitivity, specificity and predictive value of MS-CT to detect significant obstructive coronary lesions (>50% lumenal diameter reduction with QCA) using the diagnostic invasive coronary angiogram as the reference standard. The costs, effectiveness, and the cost-effectiveness of non-invasive MS-CT coronary angiography as an initial test will be compared to diagnostic invasive coronary angiography. | — |
Contacts
Public ContactPim J. Feyter, de
Erasmus Medical Center, Department of Cardiology and Radiology, P.O. Box 2040
Outcome results
None listed