Osteoarthritis of the knee is a progressing degenerative joint disorder, characterised by joint pain and limitation of movement, leading to disability. Tissue changes comprise damage of joint cartilage, synovial inflammation and changes in subchondral bone, such as subchondral sclerosis and osteophyte formation (bony outgrowths).
Conditions
Interventions
Joint distraction applies temporary (2 months) relief of mechanical wear and tear of the articular cartilage surfaces forming a joint. Nutrition of the cartilage is maintained due to intra-articular f
Sponsors
University Medical Center Utrecht,
Rheumatology & Clin. Immunology and Orthopaedics
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age < 55 years; 2. Osteoarthritis, primary in the tibio-femoral joint, uni or bilateral; 3. Severe osteoarthritis considered for joint replacement surgery/osteotomy.
Exclusion criteria
Exclusion criteria: 1. Osteoarthritis in both knees; 2. Primary retro-patellar osteoarthritis; 3. Deviation of the mechanical axis >10 º (independent of cartilage damage); 4. Primary intra-articular inflammation; 5. Psychological problems, not allowing 2 months distraction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain (according to the WOMAC). | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional disability (according to the WOMAC). | — |
Contacts
Public ContactA.C.A. Marijnissen
University Medical Center Utrecht (UMCU), Department of Rheumatology and Clinical Immunology, F02.127, P.O. Box 85500
Outcome results
None listed