Studie naar ontstekingsmechanismen in patiënten met fistels bij de ziekte van Crohn

Lymphocyte trafficking in patients with fistulizing Crohn's disease, a descriptive study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20469

Enrollment

Registered

2018-01-24

Start date

2016-07-06

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perianal fistula, Crohn's disease, lymphocyte trafficking, vedolizumab, perianale fistels, ziekte van Crohn.

Interventions

- Flushing of sodium chloride 0,9% through the fistula tract, collection for flow cytometric analysis.

Eligibility

Inclusion criteria

Inclusion criteria: - Group 1: CD patients with perianal fistula, referred for surgical treatment including seton placement and/or advancement flap plasty. * Diagnosis of CD, established by clinical and endoscopic evidence and corroborated by a histopathology report * Age ≥ 18 years, either male or female * Ability to give informed consent - Group 2: Patients with cryptoglanudular perianal fistula, without CD, referred for surgical treatment * Age ≥ 18 years, either male or female * Ability to give informed consent

Exclusion criteria

Exclusion criteria: - Inability to give informed consent

Design outcomes

Primary

Measure	Time frame
To demonstrate key-players of lymphocyte trafficking in infiltrates and neoangiogenesis of fistula tracts in patients with Crohn’s disease and compare this with cryptoglandular fistula.	—

Contacts

Public ContactCyriel Y. Ponsioen

Department of Gastroenterology & Hepatology Academic Medical Center P.O. Box 22700

c.y.ponsioen@amc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)