Sepsis
Conditions
Interventions
The study is diagnostic and prognostic without an intervention. The following variables are obtained for the development of a clinical decision tool:
Age
temperature
blood pressure
heart rate
respiratory rate
oxygen saturation
rigors
acute clinical deterioration
C-reactive protein
procalcitonin
Sponsors
UMC Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: 1)Adult patients (>18 years) 2)Home visit by a general practitioner from an out-of-hours service 3)Acutely ill patients with fever, confusion or general deterioration or otherwise suspected of a serious infection.
Exclusion criteria
Exclusion criteria: 1) No informed consent 2) Non-infectious cause of the acute complaints, e.g. stroke or myocardial infarction. 3) Hospitalisation less than 7 days before the home visit. 4) Condition that requires secondary care assessment in case of any signs of systemic infection (eg chemotherapy with possible neutropenia). 5)Terminal illness or other reason not to refer the patient to a hospital despite presence of a life-threatening condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is diagnosis of sepsis within 72 hours of inclusion. The reference standard is an expert panel assessment (following the SEPSIS-3 definitions) | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of sepsis 30-day mortality Hospital and ICU admission within 72 hours and length of hospital stay. Cost-effectiveness | — |
Contacts
Public ContactFeike Loots
UMC Utrecht, div. Julius Center
Outcome results
None listed