Prediabetes, hypertension
Conditions
Interventions
Sponsors
TKI funded project with industrial sponsors Nunhems, Agrico Research and Avebe
Eligibility
Inclusion criteria
Inclusion criteria: Age between 50 and 70 BMI higher or equal to 27 kg/m2 Impaired fasting glucose (fasting glucose = 5.6 and = 6.9 mmol/L) or/and Impaired glucose tolerance (glucose levels = 7.8 and = 11.1 mmol/L, 2-hours after an OGTT or/and glucose levels =8.6 mmol/L, 1-hour after an OGTT)
Exclusion criteria
Exclusion criteria: Has been diagnosed with diabetes Having other conditions, like liver, pancreatic, cardiovascular, gastro-intestinal or endocrine diseases, that could influence the study results Use of medications or supplements that could influence the study results Sensitive to medical skin adhesives More than 5kg weight change in the past 12 weeks Excessive alcohol consumption (>21 glasses/week for men and >14 glasses/week for women on average) Being an employee of Wageningen University, division Human Nutrition and Health Currently a research subject in other research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial glycaemic response during a 2 hour oral glucose tolerance test (OGTT) | — |
Secondary
| Measure | Time frame |
|---|---|
| Other parameters of type 2 diabetes risk: o Postprandial insulin and glucagon response during a 2 hour OGTT, measured at baseline, 30, 60 and 120 minutes after intake of the glucose drink o Plasma free fatty acids before and after the intervention o HbA1c before and after the intervention period o Interstitial glucose every 15 minutes during 14 days before and after the intervention period with a FGM device ? During 5 days of normal eating before and after the intervention period o Blood pressure ? Single measurement before and after the intervention ? Dynamic measurement during an entire day, before and after the intervention and after a single dose of GABA • Mean day SBP and DBP • Mean night SBP and DBP • Time below or above 120/80 mmHg o Heart rate o Markers of inflammation in blood o TG and LDL and HDL cholesterol o Liver enzymes ALAT and ASAT Acute effects of GABA o Postprandial glucose after an OGTT, measured with the freestyle libre sensor o Dynamic blood pressure for 24 hours Other o PSQI sleep questionnaire, PHQ-9 depression questionnaire and GAD-7 anxiety questionnaire o GABA and glutamate plasma levels before and after the intervention | — |
Contacts
Public ContactTessa de Bie
Wageningen University
Outcome results
None listed