Invloed van inspanning door middel van wielrennen op het haemostatisch profiel.

Effect of cycling exercise on the haemostatic profile.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20436

Enrollment

Registered

2013-02-08

Start date

2013-04-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise, coagulation, platelet reactivity, thrombin generation, endofibrosis, cycling

Interventions

Blood will be collected before and after long-term strenuous exercise. Coagulation profile will be measured bij Thrombin Generation (CAT), Rotem

Natem and by measuring Thrombin-Antithrombin complex , Coagulation Factor XIa (FXIa), tissue Plasminogen Activator (tPA), D-Dimer and von Willebrand Factor (vWf). Platelet reactivity will be assesed b

Eligibility

Inclusion criteria

Inclusion criteria: 1. Minimal 18 years old; 2. Trains more than 3 times a week; 3. Mentally competent.

Exclusion criteria

Exclusion criteria: 1. Diagnosed with coagulation or platelet disorder; 2. Using medication against coagulation or platelet function; 3. Vascular operation within 6 months before the research; 4. BMI > 30; 5. Prestation influencing drugs; 6. Pregnancy.

Design outcomes

Primary

Measure	Time frame
Expecting to show increased coagulation activity by increased TAT levels, supported by decreased Coagulation Time (CT) and enhanced Maximal clotting formation (MCF) by Rotem and enhanced thrombin generation through CAT assay. Increased fibrinolytic activity is expected by increased tPA and D-Dimer levels. Coagulation activation via the intrinsic pathway can be showed by enhanced thrombin generation in Active Side Inhibitor factor Seven (ASIS) assay. Increased platelet reactivity is expected by multiplate accompanied by a increase in platelet count. Moreover we expect increase vWf levels, due to endothelial dysfunction.	—

Measure

Time frame

Expecting to show increased coagulation activity by increased TAT levels, supported by decreased Coagulation Time (CT) and enhanced Maximal clotting formation (MCF) by Rotem and enhanced thrombin generation through CAT assay. Increased fibrinolytic activity is expected by increased tPA and D-Dimer levels. Coagulation activation via the intrinsic pathway can be showed by enhanced thrombin generation in Active Side Inhibitor factor Seven (ASIS) assay. Increased platelet reactivity is expected by multiplate accompanied by a increase in platelet count. Moreover we expect increase vWf levels, due to endothelial dysfunction.

—

Secondary

Measure	Time frame
Secondary outcomes can be a change in Hematocrit and Haemoglobin, due to plasma volume changes. Moreover, outcomes can be that cycling exercise induces a internal haemostatic profile that can contribute to pathofysiological disease which are very common in cycling, endofibrose of the iliacal artery. Characterized by subendothelial fibrotic tissue formation. Protease Activated Receptors are known that they can induce fibrotic tissue formation and can be activated by coagulation factors (FXa and Thrombin).	—

Measure

Time frame

Secondary outcomes can be a change in Hematocrit and Haemoglobin, due to plasma volume changes. Moreover, outcomes can be that cycling exercise induces a internal haemostatic profile that can contribute to pathofysiological disease which are very common in cycling, endofibrose of the iliacal artery. Characterized by subendothelial fibrotic tissue formation. Protease Activated Receptors are known that they can induce fibrotic tissue formation and can be activated by coagulation factors (FXa and Thrombin).

—

Contacts

Public ContactJelle Posthuma

Universiteitssingel 50 Room 4.330

jelle.posthuma@student.maastrichtuniversity.nl+31 (0)43 3881542

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)