Painful Locally advanced or locally recurrent pancreatic cancer
Conditions
Interventions
radiotherapy 3 X 8 Gy, once per week.
Sponsors
Academic Medical Center
Meibergdreef 9
1105 AZ Amsterdam, the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pain with a NRS ¡Ý 2 as a result of pancreatic cancer, not sufficiently responding to oral, transdermal pain medication or celiac plexus blockade. 2. Primarily irresectable or locally recurrent pancreatic cancer with or without metastases 3. Preferably histological or cytological confirmed adenocarcinoma of the pancreas 4. WHO performance status ¡Ü 2 5. Diagnostic CT-scan not older than 3 months before study entry 6. Age ¡Ý 18 years 7. If the patient is or was treated with chemotherapy, time interval between the course of chemotherapy and start of radiation should at least be 14 days. 8. Written informed consent 9. The ability to answer and fill out the questionnaires
Exclusion criteria
Exclusion criteria: 1. Resectable or borderline resectable tumors without distant metastases 2. Endocrine pancreatic cancer or suspicion of metastasis in the pancreas 3. Pregnant woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate whether pain relief is successful 4 weeks after the last radiation (7 weeks after start of treatment) . A short course of radiation (3 x 8 Gy) will be given in patients with painful irresectable pancreatic cancer, primary or recurrent. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To determine the effect on pain free interval • To determine the reducing effect on (opiod) pain medication • To evaluate the effect on acute toxicity • To evaluate the correlation of radiation volume with acute toxicity • To evaluate the effect on quality of life • To evaluate the overall survival | — |
Contacts
Public ContactG. van Tienhoven
Academic Medical Center - Meibergdreef 9
Outcome results
None listed