Prediction of REsPonse to Antipsychotics using electRoEncephalography

Prediction of REsPonse to Antipsychotics using electRoEncephalography: Handling Antipsychotic Medication: developing a biomarker to predict medication response

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20422

Enrollment

100

Registered

2020-06-23

Start date

2020-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychosis

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Age between 16 and 40 years old - First psychotic episode, with a classification of schizophrenia, schizophreniform disorder or psychosis not otherwise specified. - Patients need to be antipsychotic medication naïve. Short treatment in the past with antipsychotics is permitted if patients received a dose and duration of the treatment not high enough to expect response. - Patients who are or will be treated with antipsychotics. - Comorbidity is allowed. - The participant needs to understand the study and is able to provide written informed consent. - We will ask patients not to take benzodiazepines 24 hours before the EEG recordings.

Exclusion criteria

Exclusion criteria: - Coercive measures - A history of mental retardation, - Organic brain damage - Organic psychosis. - Patients who are pregnant of patients who are breastfeeding.

Design outcomes

Primary

Measure	Time frame
Remission or response based on PANSS scores	—

Secondary

Measure	Time frame
Functional well-being, DNA methylation,	—

Contacts

Public ContactLivia Dominicus

umc Utrecht

l.s.dominicus-2@umcutrecht.nl0613204315

Outcome results