Healthy first time marathon runners
Conditions
Interventions
None listed
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: · Men aged between 35-50 · No known (uncontrolled) medical illness · Has no history of surgery for the past 2 years · Does not suffer from musculoskeletal injury · Has not run or trained for a marathon before · Has not run further than 21.1 km in one single race or training in the last year · Has never trained or competed on a semi-professional or professional level in endurance sports · Agree and signed the informed consent to participate in this study Subgroup: If possible, we will aim to include 12 participants (half of study sample) with a documented covid 19 history (PCR positive) without hospitalization for the past 6 months.
Exclusion criteria
Exclusion criteria: · Classified as high risk (symptomatic, or known cardiovascular, pulmonary, renal or metabolic disease) according to ACSM guideline · Contraindications for MRI scanning (claustrophobia or other contra-indication for MRI) · Glomerular filtration rate < 30 ml/min · Illiterate or unable to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI characterization of myocardial (mal)adaptation of marathon training and participation as assessed by left and right ventricular end-diastolic and end-systolic volumes (with the corresponding stroke volumes and ejections fractions), mass and wall thickness. | — |
Secondary
| Measure | Time frame |
|---|---|
| · Echocardiography: The functions of cardiac systolic, diastolic, left ventricle, right ventricle, valves and dimensions · ECG: Detection any ECG abnormalities · CPET: VO2max · Heart rate: Exercise intensity, resting heart rate · Cardiac biomarkers: Troponin I and T, N-T pro BNP, CT-1 and Galectin-3 · Cardiomyocyte integrity: LGE, mean diffusivity (MD), extracellular volume fraction (ECV) | — |
Contacts
Public ContactInarota Laily
Amsterdam Medisch Centrum
Outcome results
None listed