None listed
Conditions
Interventions
None listed
Sponsors
LUMC (Leidsch University Mediccal Center)
Eligibility
Inclusion criteria
Inclusion criteria: 1. > two subsequently miscarriages; 2. Maternal age < 40.
Exclusion criteria
Exclusion criteria: 1. Parental chromosomal abnormalities; 2. Uterus anomalies; 3. Cervical insufficiency; 4. Untreated thyroid disease; 5. Patient mentally or legally incapacity; 6. Any history of/ or recent alcohol or drug abuse; 7. Poor balance or treatment of diabetes mellitus; 8. ART (assisted reproductive technology) pregnancies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To describe maternal immune responses in women with miscarriages compared to women with an ongoing pregnancy and women with a normal pregnancy at different gestational periods; 2. To research which role medication (progesteron, anticoagulantia) plays in the immune response and pregnancy outcome; 3. To research whether specific KIR genes combined with specific HLA-C ligands determines or influences pregnancy outcome; 4. To research the presence of KIR and KAR on NK cells, and their effect on cytokine profiles during pregnancy and pregnancy outcome; 5. To research whether the proportion of Th1 cells compared to the proportion of Th2 cells influences pregnancy outcome; 6. To study the presence of C4d deposition in placental tissue in patients with recurrent miscarriage in relation to the presence of autoantibodies, allo-antibodies and to pregnancy outcome; 7. To determine whether cytokines, chemokines or sHLA-1 in sperm influences pregnancy outcomes. | — |
Contacts
Public ContactK.W.M. Bloemenkamp
PO Box 9600
Outcome results
None listed