Colorectal cancer
Conditions
Interventions
None
Sponsors
Erasmus MC (s-Gravendijkwal 230 3015 CE Rotterdam P.O. Box 2040, 3000 CA Rotterdam Phone: +31 10 704 0704) and Sysmex Europe (Postbus 251 4870 AG Etten-Leur Phone: +31(0)765086000)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Referral for a diagnostic colonoscopy because of (new) bowel symptoms. 2. Able to undergo colonoscopy.
Exclusion criteria
Exclusion criteria: Subjects will be excluded if they are referred for colonoscopy surveillance for other indications (including hereditary CRC syndrome, familial CRC syndrome, inflammatory bowel disease, history of colorectal adenoma or CRC)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The performance of 2-sample FIT to detect advanced neoplasia by defining its negative predictive value, positive predictive value, sensitivity and specificity. | — |
Secondary
| Measure | Time frame |
|---|---|
| The added value in NPV for performing two FIT’s instead of one will be evaluated by describing the added value in NPV (d). We will describe the performance of a selection model that combines both symptoms, patient characteristics and FIT to detect advanced neoplasia by defining its negative predictive value, positive predictive value, sensitivity and specificity. We will also describe the performance of FIT for different cut-off values by the above mentioned test characteristics. | — |
Contacts
Public ContactManon Spaander
Erasmus MC
Outcome results
None listed