Cognitive functions in frequent cannabis users
Conditions
Interventions
Cannabis (400 µg/kg bodyweight THC) in combination with alcohol to reach 0,0, 0,5 and 0,8 mg/ml BAC.
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Free from psychotropic medication; 2. Good physical health as determined by medical examination and laboratory analysis (Appendix 1); 3. Absence of any major medical, endocrine and neurological condition; 4. Normal weight, body mass index (weight/length2) between 18 and 28 kg/m2; 5. Written Informed Consent; 6. To check whether subjects are high experienced users, a blood sample from the screening will be tested. THC in blood has to be >= 3,5 ng/ml; 7. Participants are smokers with a maximum of 25 cigarettes/day.
Exclusion criteria
Exclusion criteria: 1. History of drug abuse or addiction (other than the use of cannabis); 2. Pregnancy or lactation; 3. Excessive drinking (> 21 alcoholic consumptions a week); 4. No experience with alcohol; 5. Excessive smoking (>25 cigarettes/day); 6. Hypertension (diastolic> 100; systolic> 170); 7. Current or history of psychiatric disorder; 8. Color-blindness; 9. Dyslexia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the pharmacokinetic and pharmacodynamic parameters of THC in combination with alcohol as a function of time. | — |
Contacts
Public ContactE.L. Theunissen
Outcome results
None listed