Patients with epilepsy (intracranial registration)
Conditions
Interventions
Sponsors
Maastricht University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: • Medically refractory epilepsy • Diagnostic workup up till that moment has not led to decline the patient for resective epilepsy surgery • A suspected (neo-)cortical seizure focus at the surface of the brain • Planned implantation of intracranial electrodes • Incapacitating epilepsy or seizures • Minimum age 18 years Inclusion criteria for healthy control: • Voluntary controls will be selected based on the gender and age distribution of the patients programmed for grid implantation surgery.
Exclusion criteria
Exclusion criteria: • Patients with (co-existent) psychogenic, non-epileptic attacks, or low IQ (below 70). • (post-ictal) psychosis during the registration period will lead to exclusion from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the patterns and topographical distribution of the electrical signal generated in cortical neurons during the processing of sensory stimuli (of which the nature will depend on the primary function of the cortical area under investigation) in epileptic patients under intracranial registration. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives are: 1. To study the phase-amplitude relationship between different frequency bands in the neural signal. 2. To characterize the brain activation patterns during sensory stimulation by fMRI in epileptic patients before the implantation of the electrodes and compare it with the fMRI activation patterns obtained from healthy volunteers. 3. To identify the patterns in the ECoG signal that are correlated with the patterns of activation obtained with fMRI in order to understand better how the neural processes are reflected in neuroimaging studies. 4. To collect quantitative information that can be used for future research projects. | — |
Contacts
Public ContactR. Rouhl
PO Box 5800
Outcome results
None listed