Pheochromocytoma, paraganglioma, diagnosis, metanephrines
Conditions
Interventions
Collecting saliva and collecting 20 ml blood.
Filling out a anxiety questionnaire
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Patients (age > 18 years) with a pheochromocytoma or sympathetic paraganglioma, with elevated plasma metanephrines AND Germline mutation carriers without elevated plasma metanephrines AND Healthy subjects
Exclusion criteria
Exclusion criteria: The need to use medication known to influence plasma metanephrines concentration: tricyclic antidepressants, phenoxybenzamine, MAO-inhibitors, sympathomimetics, cocaine, methyldopa
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The diagnostic accuracy (sensitivity and specificity) of salivary levels of metanephrines | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To evaluate the self-reported anxiety levels in patients with a PCC/sPGL, in comparison with healthy subjects and germline mutation carriers without elevated plasma metanephrines levels and to correlate the anxiety levels to the plasma metanephrines levels 2. To determine whether position (sitting vs. supine position) influences salivary metanephrines levels. 3. To establish a reference set for plasma and salivary metanephrines in supine position after 30 minutes of rest 4. To compare the ROC curves for the PCC/sPGL patients with the ROC curve of salivary and plasma metanephrines of asymptomatic germline mutation carriers. | — |
Outcome results
None listed