Heavy water method for protein synthesis

The efficacy and applicability of oral 2H2O dosing to measure in vivo human skeletal muscle protein synthesis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20277

Enrollment

Registered

2015-03-12

Start date

2015-05-01

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

No health problems studied

Interventions

Single-legged resistance exercise training

Eligibility

Inclusion criteria

Inclusion criteria: • Healthy males • Age between 18 and 35 y • BMI between 18.5 and 30 kg/m2 • Moderate level of physical activity (exercising 2-4 hours per week)

Exclusion criteria

Exclusion criteria: • Celiac disease • Lactose intolerance • Smoking • Diabetes • Cancer • Cardiovascular Disease • Donated blood within the last 3 months • Diagnosed GI tract diseases • Arthritic conditions • A history of neuromuscular problems • Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Design outcomes

Primary

Measure	Time frame
Muscle protein synthesis (MPS) rates	—

Secondary

Measure	Time frame
Plasma free L-[2,3,3,3-2H4]-alanine enrichment (expressed as MPE) Saliva 2H2O enrichment (Expressed as APE)	—

Contacts

Public ContactA. Holwerda

Universiteitssingel 50

andy.holwerda@maastrichtuniversity.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)